Motor neuron degeneration (mnd)
In homozygous mnd mice, the retinal degeneration occurs before neuromuscular dysfunction. The retinal degeneration was nearly complete by 6 months of age, but the motor neuron abnormalities began around 6 months of age. It is a good model for human Batten diseases and its expression is clearly recessive.
|
Gene |
Mouse Chromosome |
Human Chromosome |
Retinal ONL disappear by |
Strains |
| mnd | 8 | 8p or 13q | 6 | B6.KB2-mnd |
