Vitiligo (vit, now Mitfmi-vit)
Mitfmi-vit homozygotes show a slow progressive loss of photoreceptor cells, cosegregating with the gradual depigmentation. The outer plexiform layer is significantly thinner by 4 months and the rows of photoreceptor cells are lost at a rate of about one per month beginning at 2 months of age. Retinal detachment is observed in some vitiligo mice.
|
Gene |
Mouse Chromosome |
Human Chromosome |
Retinal ONL disappear by |
Strains |
| Mitfmi-vit | 6 | 3p14 | 10 | C57BL/6J-Mitfmi-vit |
