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The Jackson Laboratory Genomic Education division specializes in developing lessons, activities, and hands-on laboratory protocols for teaching and learning about genetics and genomics. The resources below include our Teaching the Genome Generation protocols and lessons, Mighty Mice in Space lesson series, and more. Most content is created for high school teachers and students in grades 9-12, but may be suitable for other audiences.
The TtGG program offers teacher PD in genetics with NGSS-aligned molecular biology lab protocols, bioinformatics, and bioethics lessons.
This gene sheet provides details about the ACE gene and the variants examined in the TtGG laboratory protocols.
This gene sheet provides details about the ACTN gene and the variants examined in the TtGG laboratory protocols.
Our Bioinformatics lessons illustrate how computational analyses and big data sets drive important discoveries in genetics and genomics.
This tutorial guides learners through using BLAST to identify a gene from a nucleotide sequence and to compare DNA and protein sequences.
This series of short tutorial videos demonstrate how to use BLAST to compare nucleotide and protein sequences.
Students join three different research teams to learn about cancer genetics and identify treatments for melanoma.
A series of video interviews highlighting the diversity of jobs and career paths in biomedical science.
This tutorial introduces the cBioPortal and guides learners through locating and interpreting data from a cancer research study.
The series of short tutorial videos demonstrate how to navigate the cBioPortal to locate and interpret data from a cancer research study.
Students learn about COVID-19 diagnostic testing and research career possibilities in a clinical lab.
This gene sheet provides details about the CYP gene and the variants examined in the TtGG laboratory protocols.
This laboratory protocol instructs students in DNA Extraction using saliva collection kits and begins the TtGG the genotyping experiment.
This laboratory protocol instructs teachers in DNA Extraction using saliva collection kits and begins the TtGG the genotyping experiment.
This laboratory protocol instructs students in DNA Extraction using cheek swabs and begins the TtGG the genotyping experiment.
This laboratory protocol instructs teachers in DNA Extraction using cheek swabs and begins the TtGG the genotyping experiment.
This laboratory protocol instructs students in Gel Electrophoresis and variant detection in the TtGG the genotyping experiment.
This laboratory protocol instructs teachers in Gel Electrophoresis and variant detection in the TtGG the genotyping experiment.
In this virtual lab simulation, you will learn how to perform gel electrophoresis and determine genotypes of the human ACE gene.
This scrollable interactive provides a comprehensive understanding of genetic variation and explores how molecular differences contribute to phenotypic traits.
Identify variants associated with a rare disorder using BLAST, and assess variant impact on mRNA and protein sequences using percent identity calculations.
Find our digital resources on LabXchange, a global science classroom open to every curious mind.
Students are introduced to the Mice in Space project research goals and predict the outcomes of experiments.
Students graph real data from Mice in Space experiments and interpret the results.
A research poster template that serves as an accompaniment to Mice in Space Lesson 3.
Students embark on their own research project to investigate a human bone or muscle disorder.
Mighty Mice researchers published the first results from their experiments in the Proceedings of the National Academy of Sciences journal.
Teachers can use this guide to learn about the series of three lessons designed for high school students around the Mighty Mice in Space research project.
This laboratory protocol instructs students in micropipetting volumes of colored water to make a rainbow from only three primary colors.
This laboratory protocol instructs teachers in micropipetting volumes of colored water to make a rainbow from only three primary colors.
In this lesson, students assess the validity of a new Alzheimer's Disease therapeutic based on a mouse model.
This gene sheet provides details about the OXTR gene and the variants examined in the TtGG laboratory protocols.
This laboratory protocol instructs students in the PCR step of the TtGG the genotyping experiment.
This laboratory protocol instructs teachers in the PCR step of the TtGG the genotyping experiment.
Bioethics resources are available through our educational partner, the Personal Genetics Education Project (pgEd).
This tutorial introduces the Polymorphism Phenotyping v2 (PolyPhen-2) tool and guides learners through using PolyPhen-2 to predict the effect of a DNA variant on protein…
The series of short tutorial videos demonstrate how to use Polymorphism Phenotyping v2 (PolyPhen-2) to predict the effect of a DNA variant on protein function.
This laboratory protocol instructs students in the step to prepare a sample for sequencing in the TtGG the genotyping experiment.
This laboratory protocol instructs teachers in the step to prepare a sample for sequencing in the TtGG the genotyping experiment.
The infographic outlines the key steps for preparing amplified DNA products for sequencing, and provides an overview of some common purification protocols.
Full video demonstrations of the Teaching the Genome Generation laboratory protocols.
This laboratory protocol instructs students in restriction enzyme digestion of PCR products for the TtGG the genotyping experiment.
This laboratory protocol instructs teachers in restriction enzyme digestion of PCR products for the TtGG the genotyping experiment.
This protocol instructs students in the detection of DNA variants from Sanger sequence files, the final step of the TtGG the genotyping experiment.
This protocol instructs teachers in the detection of DNA variants from Sanger sequence files, the final step of the TtGG the genotyping experiment.
This gene sheet provides details about the TAS2R38 gene and the variants examined in the TtGG laboratory protocols.
This case study guides students through publicly available bioinformatics databases to solve a medical mystery.
Student activity introducing what information can be revealed in ancestry tests.
Student activity analyzing SNP genotyping data and calculating allele frequencies in populations. Paper-based using…
Student activity analyzing SNP genotyping data and calculating allele frequencies in populations…
Full teacher guide with lesson descriptions, implementation strategies, NGSS alignments, and supporting materials.
Discussion prompts focused on the ethics of genetic testing in cancer and consent.
Student activity to sort real patient data on the cBioPortal and to learn about hereditary cancer.
Student activity with graphical analyses to demonstrate how environmental factors contribute to cancer risk.
Student activity to uncover hereditary cancer using BLAST to perform DNA sequence comparisons.
Introduction to the module theme of newborn sequencing and cancer genetics.
Student inquiry project using cBioPortal to find and analyze data and determine if specific gene variants are associated with hereditary cancer.
Full teacher guide with lesson descriptions, implementation strategies, NGSS alignments, and supporting materials.
Full teacher guide with lesson descriptions, implementation strategies, NGSS alignments, and supporting materials.
The TtGG program offers teachers a modern genetics curriculum with NGSS-aligned molecular biology lab protocols, bioinformatics, and…
Student activity using bioinformatics tools PolyPhen-2, UniProt, and BLAST to investigate how a DNA variant can impact protein structure and…
Reflection on guiding questions and bioethics discussion about rare disease research and inequities in access.
Reading and questions to introduce second module theme. Focuses on a family who participated in a rare disease research study.
Student activity using ACE to practice applying sequence comparison and percent identity calculations between individuals and across species.
Student activity using ACTN3 to practice applying sequence comparison and percent identity calculations between individuals and across species.
Student activity using CYP2C19 to practice applying sequence comparison and percent identity calculations between individuals and across species.
Reading and knowledge check that introduce sequence comparison and percent identity calculations.
Student activity using OXTR to practice applying sequence comparison and percent identity calculations between individuals and across species.
Student activity using TAS2R38 to practice applying sequence comparison and percent identity calculations between individuals and across species.
Full teacher guide with lesson descriptions, implementation strategies, NGSS alignments, and supporting materials.
Student activity establishing genotype-phenotype associations using real TAS2R38 allele data and statistical…
Student activity establishing genotype-phenotype associations through statistical analysis (chi-square) using…
Full teacher guide with lesson descriptions, implementation strategies, NGSS alignments, and supporting materials.
This tutorial introduces the Universal Protein Resource (UniProt) and guides learners through using UniProt to locate functional information about a protein of interest.
The series of short tutorial videos demonstrate how to search the Universal Protein Resource (UniProt) to locate functional information about a protein.
Students and teachers are invited to visit our labs virtually. Meet scientists, explore career paths, tour the lab, jump into activities, and more!
The Virtual TtGG course offers teachers free, self-paced PD in genetics with NGSS-aligned molecular biology lab protocols, bioinformatics, and …
Students will "jump into bioinformatics" by exploring two databases in search of specific genetic information.
