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We develop innovative preclinical models and services that enable informed decision making and compound evaluation during in vivo research. De-risk drug development and move your therapeutic into the clinic faster.
JAX Preclinical Services offers the most translational and predictive efficacy, pharmacokinetics (PK) and safety testing for therapeutics such as monoclonal antibodies, bispecifics, CAR-T, antibody-drug conjugates, and combination therapies.
By combining genetically defined tumors with innovative humanized mouse models, JAX enables the validation of therapeutic candidates in an array of in vivo research that better recapitulate the human condition.
The genetic background of a strain profoundly affects the phenotype and potential applications of a mouse model. JAX strains are carefully selected for scientific value and notable characteristics, and thoroughly curated to provide you with the knowledge you need to select the right model for your in vivo testing studies with confidence.
We provide a variety of tools and services for modeling etiology and studying immune responses. Our Preclinical Research Service offerings incorporate innovation, dependability, and a dedication to customer satisfaction to help you move from concept to IND faster.
JAX can work with you to collect IND-enabling data from your in vivo pharmacology studies. We offer multiple validated routes of administration combined with a variety of behavioral, molecular, in-life and postmortem assays.
Learn about the ways in which JAX can support your research in the areas of neurodegenerative, neuromuscular, and neurodevelopmental disorders. JAX offers tailored models and efficacy studies for your preclinical research.
Discover JAX's Oncology models and efficacy studies. Evaluate your CAR or Antibody based therapeutics using JAX's cutting-edge immune-humanized mice featuring characterized PDX tumors.
Analyze the human immune and tumor environment to assess the efficacy of your therapeutic through a safety or pharmacokinetic in vivo study using a mouse model with a humanized immune system.
Assess therapeutic antibodies and compounds, which include preclinical studies on GvHD using immune humanized mouse models incorporating CD34+ and PBMC donors.
Conduct tailored efficacy studies for assessing new and established therapeutic compounds for various autoimmune disorders, including Lupus, Type 1 Diabetes, and Psoriasis.
JAX offers the world's largest collection of spontaneous, targeted, and transgenic mutant mouse strains, hundreds of which model rare diseases, for preclinical research.
Selecting the appropriate model is crucial for metabolic research. Discover the ideal model for your research needs from JAX's extensive selection of diabetes and obesity mouse models. Our collection includes a variety of NASH models and diet-induced models to enhance your in vivo study.
Antibodies are powerful tools for treating cancer, immunological disorders, and CNS diseases, but developing antibody therapeutics requires advanced tools and expertise. JAX provides next-generation transgenic mice for antibody discovery and humanized models for evaluating pharmacokinetics, efficacy, and safety to accelerate your research.
Gain insight from JAX’s experience in vivarium operations, mouse genetics, breeding, husbandry, surgical techniques, and more. With an assessment of your specific preclinical research needs, JAX can provide guidance on recommended studies or institutional approaches, as well as support in their implementation.
A glimpse at the wide range of platforms and services JAX offers to help move you from drug discovery to IND filing.
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