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Emily Swanzey, Ph.D.

Postdoctoral Associate

I am interested in using systems genetics to study gene by environment interactions in mouse pluripotent stem cells.

Visit The Reinholdt Lab

Location

Bar Harbor, ME

Contact

207-288-6000

[email protected]

My work is focused on dissecting gene by environment interactions in mouse pluripotent stem cells with the use of the Diversity Outbred population. Using systems genetics, I aim to understand how genetic variants interact with environmental cues to drive phenotypic variation.

Selected Publications

95Aronson BE, Scourzic L, Shah V, Swanzey E, Kloetgen A, Polyzos A, Sinha A, Azziz A, Caspi I, Li J, Pelham-Webb B, Glenn RA, Vierbuchen T, Wichterle H, Tsirigos A, Dawlaty MM, Stadtfeld M, Apostolou E. A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus. Dev Cell. 2021 Nov 22; 56(22):3052-3065.e5
112Swanzey E, O'Connor C, Reinholdt LG. Mouse Genetic Reference Populations: Cellular Platforms for Integrative Systems Genetics. Trends Genet. 2021 Mar; 37(3):251-265
62Vidal SE, Polyzos A, Chatterjee K, Ee LS, Swanzey E, Morales-Valencia J, Wang H, Parikh CN, Amlani B, Tu S, Gong Y, Snetkova V, Skok JA, Tsirigos A, Kim S, Apostolou E, Stadtfeld M. Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency. Stem Cell Reports. 2020 Dec 8; 15(6):1233-1245
Swanzey E, McNamara TF, Apostolou E, Tahiliani M, Stadtfeld M. A Susceptibility Locus on Chromosome 13 Profoundly Impacts the Stability of Genomic Imprinting in Mouse Pluripotent Stem Cells. Cell Rep. 2020 Mar 17; 30(11):3597-3604.e3
92Raviram R, Rocha PP, Luo VM, Swanzey E, Miraldi ER, Chuong EB, Feschotte C, Bonneau R, Skok JA. Analysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate. Genome Biol. 2018 Dec 13; 19(1):216
53Liu Y, Wang Z, De La Torre R, Barling A, Tsujikawa T, Hornick N, Hanifin J, Simpson E, Wang Y, Swanzey E, Wortham A, Ding H, Coussens LM, Kulesz-Martin M. Trim32 Deficiency Enhances Th2 Immunity and Predisposes to Features of Atopic Dermatitis. J Invest Dermatol. 2017 Feb; 137(2):359-366
24Swanzey E, Stadtfeld M. A reporter model to visualize imprinting stability at the Dlk1 locus during mouse development and in pluripotent cells. Development. 2016 Nov 15; 143(22):4161-4166
41Rocha PP, Raviram R, Fu Y, Kim J, Luo VM, Aljoufi A, Swanzey E, Pasquarella A, Balestrini A, Miraldi ER, Bonneau R, Petrini J, Schotta G, Skok JA. A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination. Cell Rep. 2016 Jun 28; 16(1):48-55
42Raviram R, Rocha PP, Müller CL, Miraldi ER, Badri S, Fu Y, Swanzey E, Proudhon C, Snetkova V, Bonneau R, Skok JA. 4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments. PLoS Comput Biol. 2016 Mar; 12(3):e1004780
12Phillips KG, Wang Y, Levitz D, Choudhury N, Swanzey E, Lagowski J, Kulesz-Martin M, Jacques SL. Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skin. J Biomed Opt. 2011 Apr; 16(4):040503

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Emily Swanzey, Ph.D.

Postdoctoral Associate

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Selected Publications